Quantitative Systems Toxicology (QST) Modeling of Drug-Induced Liver Injury and Adaptation

Authors: Yang K
Conference: AAPS
Keywords: DDIs, DILI, DILIsym, hepatotoxicity, QST modeling
Software: DILIsym®
Division: Quantitative Systems Pharmacology (QSP)

Description

  • This talk will present how quantitative systems toxicology (QST) modeling can aid in evaluating potential drug-drug interactions (DDIs) at the hepatotoxicity mechanism level and exploring mechanisms underlying adaptation to drug-induced liver injury (DILI)
  • A case study will be presented where DILIsym, a QST modeling platform, was employed to assess potential DILI DDIs between metformin and solithromycin.

Presented at AAPS PharmSci 360 Oct. 26- Nov. 5, 2020

By Kyunghee Yang