The Effect of the Local Tissue Response on the Pharmacokinetics of Long-Acting Injectable Formulations

Authors: Shahraz A, Mullin JM, Lukacova V
Conference: AAPS
Keywords: chronic inflammation, drug diffusion, FDA, long-acting injectable formulations, pharmacokinetic
Software: GastroPlus®
Division: PBPK

Purpose

Modeling consequences of localized chronic inflammation in tissue on drug diffusion and exposure caused by prolonged therapy with long-acting formulations.

By Azar Shahraz, James Mullin, Viera Lukacova

2019 AAPS Annual Meeting PharmSci 360, November 3-6, 2019, San Antonio, Texas