Different Perspectives – Informing Drug Development Decision Making Through Complementary M&S Approaches

Authors: Patel Y
Conference: AAPS
Keywords: drug disposition, modeling and simulation, PBPK model, pbpk modeling and simulation, population PK
Division: Clinical Pharmacology and Pharmacometrics (CPP)

Outline

  • Complementary M&S approaches
  •  Introduction
  • M&S approaches to study drug disposition
  • PBPK vs population PK (PPK) models
  • Factors affecting the choice
  • Case study
  • Application of complementary M&S approach for dose determination in younger children (1 – < 24 months)

By Yogesh Patel

2019 AAPS Annual Meeting PharmSci 360, November 3-6, 2019, San Antonio, Texas