In Silico and in Vitro Simulations to Predict Idiosyncratic DILI: What is on the Horizon?

Authors: Howell BA
Conference: DILI
Keywords: drug induced liver injury (DILI), drug toxicity, hepatotoxicity, idiosyncratic DILI, in silico, in vitro, liver effects
Software: DILIsym®
Division: Quantitative Systems Pharmacology (QSP)

DILIsym Tool Overview

  • Multiple species: human, rat, mouse, and dog
    • Population variability
  • The three primary acinar zones of liver represented
  • Essential cellular processes represented to multiple scales in interacting submodels
  • Over 60 detailed representations of optimization or validation compounds with 80% success
  • Single and combination drug therapies

US FDA & AASLD DILI Conference at the University of Maryland University College May 7-8, 2019

By Brett Howell