Applying in silico-in vitro-in vivo Extrapolation (IS-IV-IVE) Techniques to Predict Exposure and Guide Risk Assessment

Authors: Lawless M
Conference: SOT
Keywords: HTPK simulation module, in silico analysis, in vitro, PBPK model, PBPK simulation, risk assessment
Software: ADMET Predictor®
Division: PBPK

Applying IS-IV-IVE Techniques to Predict Exposure and Guide Risk Assessment

  • PBPK models predict the relationship between dose and the exposure by accounting for the processes of ADMET
  •  IS-IV-IVE models allow
    – in silico and in vitro data to be extrapolated to estimate corresponding in vivo effects
  • IS-IV-IVE provides
    – efficient characterization of potential chemical risk

By Michael Lawless

Society of Toxicology 58th Annual Meeting and ToxExpo, March 10-14, 2019, Baltimore, MD