The Optimization Module in GastroPlus®

Authors: Lawless M
Keywords: Cmax, Cp-Time, deconvolution, drug dosage, GastroPlus tutorial video, optimization, PBPK modeling, PK data, plasma concentration
Software: GastroPlus®
Division: PBPK

This tutorial discusses the Optimization module in GastroPlus that allows one to optimize simulation model parameters such as initial dose, Vmax, enzyme expression levels, and many others, in order to better mimic observed values such as Cmax and Cp-time profiles.