Serial sinus aspirate samples during high-dose, short-course levofloxacin treatment of acute maxillary sinusitis

Authors: Anon JB, Paglia M, Xiang J, Ambrose PG, Jones RN, Kahn JB
Publication: Diagn Microbiol Infect Dis
Keywords: Acute Disease, administration & dosage, adult, adverse effects, anti-bacterial agents, Catheters, Dose-Response Relationship, drug, drug administration schedule, drug effects, drug therapy, female, Haemophilus Infections, Haemophilus influenzae, Indwelling
Division: Clinical Pharmacology and Pharmacometrics (CPP)

Abstract

This study assessed daily aspirate samples from an indwelling sinus catheter during high-dose, short-course levofloxacin (750 mg daily x 5 days) treatment of acute maxillary sinusitis. Pathogens were isolated from 4 of 18 recruited patients. Bacteriologic eradication occurred within 24 h for 3 patients and 72 h for the 4th.

By, Anon JB, Paglia M, Xiang J, Ambrose PG, Jones RN, Kahn JB