Assessing the Role of Intracellular Binding Protein in Drug-Induced Bile Acid Transporter Inhibition Using QuantiativeSystems Pharmacology (QSP) Modeling

Authors: Woodhead JL
Conference: AAPS
Keywords: bile acid (BA) homeostasis, bile salts, drug-induced liver injury, Quantitative Systems Toxicology (QST)
Software: DILIsym®
Division: Quantitative Systems Pharmacology (QSP)

Introduction

DILIsym Is Used to Predict Bile-Acid Mediated Drug-Induced Liver Injury

  • DILIsym is a quantitative systems toxicology (QST) model of drug-induced liver injury (DILI)
  • DILIsym has a good record of predicting DILI, including with drugs that are inhibitors of the bile salt export pump (BSEP)
  • Bosentan/telmisartan
  • Troglitazone/pioglitazone
  • Tolvaptan
  • TAK-875
  • Kidetermined from a vesicle assay is used to represent inhibition potency in the simulation

2018 AAPS Annual Meeting PharmSci 360, November 4-7, 2018, Washington, DC

By Jeffrey L. Woodhead