Simulations Plus, Inc. (AMEX: SLP), a leading provider of ADMET absorption simulation and structure-to-property prediction software for pharmaceutical discovery and development, will hold a conference call to discuss its second quarter fiscal year 2007 (ended February 28, 2007) results on Wednesday, April 25, at 4:15 p.m. Eastern Time (1:15 p.m. Pacific Time).

Shareholders and interested parties may join the conference call by dialing toll-free (800) 867-4593, and referencing either ‘Simulations Plus Second Quarter Fiscal Year 2007 Results’ or confirmation code 5588914. The conference call may also be accessed from outside the United States by dialing (785) 830-7984. Please dial-in five to ten minutes prior to the scheduled start time. Playback should be available on our web site within 72 hours.