Kinetics and Action of N-Methylthiotetrazole in Volunteers and Patients. Population-Based Clinical Comparisons of Antibiotics With and Without This Moiety

Authors: Schentag JJ, Welage LS, Williams JS, Wilton JH, Adelman MH, Rigan D, Grasela TH
Publication: Am J Surg
Keywords: anti-infectives, azoles, cefoperazone, cefotetan, cephalosporins, cephamycins, chemically induced, comparative study, humans, hypoprothrombinemias, infectious disease, moxalactam, New York, pharmacokinetics, pharmacology, population surveillance, risk, risk factors, tetrazoles, Toxicity
Division: Clinical Pharmacology and Pharmacometrics (CPP)

Abstract

Normal volunteers and patients were studied to determine the relative importance of NMTT and patient risk factors in the production of hypoprothrombinemia. The normal volunteers demonstrated in vivo NMTT production, but the order of magnitude (cefoperazone, moxalactam, and cefotetan in descending order) was different from the usual order of clinical risk. In patients, there was not a NMTT-concentration-versus-effect relationship. Patients who were vitamin K deficient were more sensitive to lower NMTT concentrations than those with normal vitamin K status. In surveillance studies, NMTT-containing antibiotics were nor more frequently associated with hypoprothrombinemia or bleeding than antibiotics that lack this moiety.

By Schentag JJ, Welage LS, Williams JS, Wilton JH, Adelman MH, Rigan D, Thaddeus H. Grasela