DDDPlus™ 4.0

NOTE:
 The definition of shape factor has been changed from length over radius to length over diameter.
NOTE: The definition of shape factor has been changed from length over radius to length over diameter.

The calculation of the bin radius has changed from using the smallest radius in the bin to the average radius in the bin.

The CMC value for CTAB was changed from 0.4 M to 0.001 M.

1. Added ability to run a parameter sensitivity analysis and obtain the complete dissolution profile

2. Added ability to run a virtual trial to assess variability effects of formulation or experiment.

3. Added a new dosage form - IR Capsule

4. Improved support file data input. 

5. Improved pKa data input.

6. Improved pH-solubility profile plot



DDDPlus
3.0

NOTE:
 Implementation of improved solubility calculation routine.  This may require you to recalibrate your old DDDPlus models. 

HCl and Phosphate buffer files that were recipes from the United States Pharmacopeia have been renamed to include the USP in front of the name.  For example, Phosphate pH 6.4 buffer has been renamed to USP Phosphate pH 6.4.

 

1. Added ability to run a parameter sensitivity analysis on buffer component concentrations

 

2. Added ability to run an optimization on buffer component concentrations to match a desireddissolution profile.

 

3. Added a USP 4 open-loop flow-through option

 

4. Improved database handling. 

 

5. Ability to view and edit database tables.

 

6. DDDPlus form resizing capability

 

7. Modified the DDDPlus user interface to resemble our GastroPlus™ program.

 

8. Added to the built-in list of excipients

 

9. Added more salt types

 

10. Added Japanese Pharmacopeia buffers

11. Added USP acetate buffers

 



DDDPlus  2.2

1. A new and faster Numerical Integrator "CVODE"for solving systems of differential equations.

2. The simulations are 4 times faster and more accurate.

3. Optimize pKa and Solubility Factors from experimental values.

4. Optimize Particle Size Distribution from D50 and D90 values etc.

5. A number of user enhancements.